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Vigabatrin vs Carbamazepine Monotherapy in Patients with Newly Diagnosed Epilepsy Arch Neurol 52:989-996, Kalviainen,R.,et al, 1995 See this aricle in Pubmed Article Abstract During the 12 month followup period,60%of patients receiving vigabatrin and carbamazepine were treated successfully.Vigabatrin caused fewer side effects that required discontinuation of therapy.However,vigabatrin had to be discontinued more often owing to lack of efficacy and fewer of the successfully treated patients receiving vigabatrin achieved total freedom from seizures.Vigabatrin had no detrimental effects on cognitive functions.Retrieval from both episodic and semantic memory and flexibility of mental processing improved significantly in patients successfully treated with vigabatrin.Vigabatrin seems to be an effective and safe antiepileptic drug as primary monotherapy for epilepsy with fewer cognitive side effects than carbamazepine.

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(click to filter results - removes previous filter) adverse drug reaction anticonvulsants,cognitive function with carbamazepine seizure,treatment of treatment of neurologic disorder vigabatrin

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